Fabtech Pharmaceutical Machines

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Tablets and capsules continue to be the most commonly manufactured oral solid dosage form in the pharmaceutical industry. Before tabletting, pharmaceutical compounds undergo granulation to improve flowability and processing. ‘Granulation is the process of collecting particles together by creating bonds between them. Bonds are formed by compaction or by using a binding agent.’ With this post, we introduce you to the science of granulation, one of the most critical operations in the oral solid dosage form manufacturing process.

Tablet or capsule quality is achieved by the granulation process and not just by compressing granules in a tablet press or filling into capsule shells. Granulation combines one or more powders to bond and form granules that allow the tabletting process to produce tablets within the specified tablet-press speed range or in automatic capsule filling machines.

Agglomeration of particles with the granulation process improves flow and compression characteristics, reduces segregation, eliminates excess amounts of fine particles, and improves the uniformity of weight to achieve uniformity in drug content. This results in fewer tablet defects, improved yield, higher productivity and reduced downtime.

A tablet or capsule formulation is made up of several ingredients, and of these, the active ingredient (API) is critical. Other ingredients offer variations in physiochemical properties such as improved flow, high bulk density, compressibility, appearance, disintegration time and dissolution rate. It is necessary to understand the nature of the active and improve on its characteristics to make the granulation process work effectively. Flowability is critical to making a good tablet. Some active ingredients are very fine, small particles, lighter than other ingredients. Sometimes, even when the active ingredient is the correct size, it may not flow smoothly.

When the active ingredient is a small portion of the overall tablet, it is necessary that each tablet has the same quantity of active ingredient. If the active is incompatible from other ingredients because of particle size, density, flow characteristics, moisture content or compressibility, this can cause segregation during blending or transfer to the tablet press.

When a tablet contains a high percentage of the active ingredient, the active ingredient must flow, compress and eject from the tablet press and properly disintegrate when administered. The active ingredient must be granulated individually before being blended with other ingredients and compressed on the tablet press.

One way to solve the segregation problem is to granulate the active ingredient by itself and then blend it with the rest. The best method to ensure each tablet contains the correct amount of active ingredient especially if it constitutes a small portion of all the tablet ingredients is to mix the active ingredient thoroughly with the other ingredients and to then granulate the blend. This allows the bond between the particles in each granule to hold together and prevents them from breaking apart before they are compressed.

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Features :

• Quick clamping arrangement for vacuum chamber lid
• Large surface are for filtration due to pleated filter bag
• Provision of shaker to remove powder from the filter bag

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Features :

• Ideal for small / medium scale pharmaceutical units which can make a significant difference in your production unit
• This machine is compact occupies minimal space, easy handling and user friendly
• More accuracy with economic production cost
• The base & covering of the machine is fabricated from stainless steel with duly polished
• Designed to fill all standard capsule sizes from 00 to 5.

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Features :

• The polishing chamber inclinations are adjustable to suit the formulation
• Provision of compressed air for cleaning the nylon brush
• The polishing chamber is to be connected to a vacuum cleaner to suck the de-dusted powder from the polishing chamber
• No change parts are required for different size of capsules
• Easy to dismantle, wash and reassemble
• Very little maintenance is required for this machine except for periodic cleaning
• Mounted on a stand with locking type wheels and can be freely moved about and taken to any place for putting it in operation

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Features :

• An extremely small machine, occupying very little space
• Sorts out diametrically defective capsules
• Output of up to 120,000 capsules per hour, depending on the capsule-filling machine

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Features of Filled Capsule Sorter :

• CGMP compliant
• Eliminate empty capsule, loose cap and body to ensure only filled capsules are in the output.
• No change parts are required for different capsule size.
• All components coming in contact with the capsules are made of stainless steel or other approved materials

Mini Capsule Sorter :MCS100 is specially designed for automatic sorting of loose caps, loose bodies and diametrically defective filled capsules.Features :

• Removes diametrically distorted capsules, loose caps, body and loose powder
• Compact in Size, taking up very little space
• All contact parts made of SS-316 and all aluminum parts are specially plated
• Sorts capsules of sizes 000 to 5

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Features :

• Sorting of filled capsules and empty capsules.
• All contact parts SS 304
• Integrated with speed controller blower.
• Can be sorted for capsule size 5 to size 000
• Small and accurate

Empty sorter is designed to sort empty capsules and semi filled capsules from the final filled capsules.